Farxiga vs Jardiance: The Comparison

Are you considering Farxiga vs Jardiance for diabetes management? 

Whether either of these are currently part of your regimen or you are seeking additional information before starting medication, this blog is for you!

As a registered dietitian and diabetes educator, I encourage individuals living with diabetes to stay educated on all aspects of diabetes management. Having the knowledge and credible information will allow you to flourish! 

This article is packed with what you need to know about Farxiga and Jardiance, two medications sharing a common goal of improving glycemic control in individuals with type 2 diabetes. 

Read this blog to start making confident choices to improve your overall health.

Understanding Diabetes

Type 1

Type 1 diabetes is an autoimmune condition that impacts the body’s ability to regulate blood sugars. While typically diagnosed in childhood or adolescence, type 1 can develop at any age. 

In type 1 diabetes, the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas.  This leads to a deficiency of insulin, the hormone that regulates blood sugar levels. 

As a result, individuals must rely on daily insulin injections or pump therapy to deliver insulin for proper management of blood sugar levels. 

Prediabetes and Type 2

Prediabetes and type 2 diabetes mellitus are conditions where you do not have enough insulin production to control your blood sugars within normal limits for optimal health.

Similar to Type 1, it is the role of your pancreas to produce insulin for your body, which can move into your bloodstream when your blood sugars are elevated (like after eating a meal or a stressful situation).

With prediabetes and type 2 diabetes, your body is not able to move this insulin into your bloodstream to reduce elevated blood sugars effectively. However, your pancreas continues to produce the insulin because your blood sugar remains elevated.

Eventually, the cells of the pancreas can wear out due to high insulin production and can stop producing insulin. When this happens, you cannot reverse the damage and other methods of managing blood sugars are needed.

With proper blood sugar control, you can prevent this progression and manage the condition effectively to live a healthy life. 

Gestational Diabetes 

Gestational diabetes mellitus (GDM) is a condition that can develop in women during pregnancy who do not already have diabetes.

It is when your body cannot produce or use insulin effectively during pregnancy, resulting in a state of chronic high blood sugars that can be harmful to both the mother and child.

GDM is often a symptom of underlying β-cell dysfunction, which is why you will see the increased risk of the mother and child developing diabetes later in life. B-cells or beta cells are cells located in the pancreas that are responsible for the storage, production and release of insulin.

With proper management through lifestyle changes, most women with gestational diabetes can maintain healthy blood sugar levels and deliver a healthy baby.

The Mechanism of Farxiga 

Farxiga, also known as dapagliflozin, is a medication that belongs to a class of drugs called sodium-glucose cotransporter 2 (SGLT2) inhibitors. 

This medication is typically prescribed to those individuals with type 2 diabetes.

Farxiga targets a specific protein in the kidneys (SGLT2), which has a crucial role in the reabsorption of glucose from the urine back into the bloodstream. By inhibiting this protein, the reabsorption of glucose is reduced and excess glucose can be excreted via urine. 

Thus, this can help lower blood sugar levels and aid in the management of type 2 diabetes. 

Other reasons that Farxiga may be prescribed are to reduce the risk of cardiovascular events or reduce the risk of death or problems in adults with kidney disease. 

How Does Jardiance Work?

Jardiance, also known as empagliflozin, is also a medication classified as SGLT2 inhibitor.

Similar to Farxiga, Jardiance is prescribed for individuals with type 2 diabetes and facilitates increased excretion of glucose through urine to lower blood sugar levels. 

Jardiance can also be prescribed to patients at risk for cardiovascular events such as heart attacks or strokes and reduce the risk of death in adults with heart disease in conjunction with type 2 diabetes.

Farxiga vs Jardiance: Drug Comparison 

While Farxiga and Jardiance share a common mechanism of action by inhibiting the SGLT2 protein in the kidneys, there are a few differences between the two medications. 

Ingredients

Farxiga contains dapagliflozin as the active ingredient while Jardiance contains empagliflozin. Both work to excrete excess glucose, but the chemical structure of each ingredient differs. 

Dosage

The recommended dosage for both medications should vary based on individual requirements. 

Typically, the initial dose of Farxiga is 5mg once daily with the option to increase based on healthcare provider recommendations. 

The standard Jardiance dosage is 10mg once daily, which also can be adjusted as needed. 

It is crucial to not follow these general dosages. Instead, adhere strictly to the prescribed dosage or consult with your healthcare provider before making any changes to your medication regimen. 

Cost

The cost of Farxiga and Jardiance cost varies based on several factors like individual health insurance coverage and prescription plans.

For the most up-to-date cost information, check with your individual plan or local pharmacy. You can also visit GoodRX for detailed cost information. 

Side Effects

Common side effects of jardiance may include bladder infections, lightheadedness, low blood sugar, dehydration or ketoacidosis. For a detailed list of more common, less common and rare side effects, visit Drugs.com.

Farxiga common side effects may involve hypotension, nausea, dehydration, dizziness, increased confusion, seizures, fast heartbeat, increased thirst or chills. For a comprehensive list of side effects, visit Drugs.com to learn more.

Frequently Asked Questions 

What is the effectiveness of Farxiga and Jardiance?

Farxiga and Jardiance have both demonstrated effectiveness in the management of type 2 diabetes.

Clinical studies have shown effective glycemic control, reduced body weight and blood pressure across a spectrum of patients taking Farxiga. 

Jardiance is seen as a valuable treatment option for the management of type 2 diabetes and demonstrated cardioprotective benefits through clinical studies

The effectiveness of both medications may vary among individuals, which is why it is extremely important to work with your healthcare team to determine which medication is appropriate for you. 

Is Farxiga better than Jardiance? 

The choice between the two medications largely depends on individual characteristics, preferences and treatment goals. 

While both share common mechanisms as described above, differences in patient response, tolerability and outcomes can differ. Aim to take a personalized approach with medication management to determine which drug is more suitable for you. 

Can you switch from Farxiga to Jardiance?

Yes, it is possible to make the switch from Farxiga to Jardiance pending the guidance and direction of your healthcare team.

This decision can be influenced by the response, tolerability, side effects and specific treatment goals. 

It is imperative for you to not self-adjust medication without consulting your healthcare provider as changes could impact overall health and diabetes management. 

What should I ask my doctor? 

Here are some common questions that you can ask your healthcare team before starting either medication or making the switch from Jardiance to Farxiga. 

  • Is Farxiga (or Jardiance) the right choice for my type 2 diabetes management? 
  • What are alternative medications or treatment options I could consider?
  • What is the dosage that I will start with?
  • Does Farxiga (or Jardiance) interact with any medication that I am currently taking? 
  • Are there any lifestyle or dietary changes that I should be aware of while taking Farxiga (or Jardiance)? 
  • How often do I need to monitor my blood sugar levels while taking medication? 
  • How often will I need follow-up appointments to understand the effectiveness of the medication? 

Flourish With Diabetes

Navigating diabetes management involves making informed decisions tailed to your individual health needs and goals. 

Both Farxiga and Jardiance have proven effective in reducing blood sugar levels, A1c and risk of major cardiovascular events. 

Use the information in this blog to have thorough discussions with your healthcare team to determine if medication is the best choice for you. 

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Springtime Nutrition, LLC was founded on my passion to partner with individuals to eliminate the stress, frustration and overwhelm of changing their nutrition lifestyle. I am committed to supporting you at every step of your journey. Ready to transform your life? Get started today!

Certified Diabetes Care & Education Specialist/ Registered Dietitian/ Owner - Springtime Nutrition, LLC <br> Kari's Full Bio

Kari is a diabetes expert with more than 18 years of experience. Kari currently works as a diabetes educator with a large hospital system in Charleston, SC and is committed to improving the lives of people with any type of diabetes.

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